Canberra Intensive Care Unit

Our mission is to contribute significantly to collaborative home-grown and multi-centre research


Our Research

The Canberra Hospital ICU has an international reputation for leading and contributing to high quality, patient-centred research which leads to improved patient experiences and outcomes around the world.

We focus on developing and conducting investigator-initiated research, collaborate on many ANZ and international projects and support a number of PhD students. Our ICU is a member of the Australia and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG).

With strong links to the Australian National University and the University of Canberra, there are many opportunities to get involved with clinical and basic science research in Canberra ICU.

Our Research Executive committee of nursing, medical and allied health clinicians provides leadership, governance and support for all ICU related research proposals and projects. For more information, please contact the Division of Critical Care, Research and Service Development Unit:

CHARM 2018

As part of Canberra Hospital’s commitment to innovation we host an annual Canberra Health Annual Research Meeting (CHARM).

CHARM aims to showcase and recognise the wide range of health research in the Canberra region. It is a joint venture between ACT Health, The Australian National University Medical School, John Curtin School of Medical Research, Australian Catholic University, The University of Canberra, The Australian Institute of Sport, University of New South Wales, Sports Medicine Australia and is organised by the ACT Health Research Office.

Current Research

Our Latest Findings

Research Publications

Swan, K. L., T. Keene and B. J. Avard (2018). "A 12-Month Clinical Audit Comparing Point-of-Care Lactate Measurements Tested by Paramedics with In-Hospital Serum Lactate Measurements." Prehosp Disaster Med: 1-7.

Dicks, S. G., K. Ranse, H. Northam, F. M. van Haren and D. P. Boer (2018). "A novel approach to studying co-evolution of understanding and research: Family bereavement and the potential for organ donation as a case study." Health Psychol Open 5(1): 2055102917753706.

Delaney LJ, C. M., Huang HC, Litton E, Wibrow B, Lopez V, Haren FV (2018). "Investigating the application of motion accelerometers as a sleep monitoring technique and the clinical burden of the intensive care environment on sleep quality: study protocol for a prospective observational study in Australia." BMJ Open.

Young, P. J., M. J. Bailey, R. W. Beasley, R. C. Freebairn, N. E. Hammond, F. M. van Haren, M. L. Harward, S. J. Henderson, D. M. Mackle, C. J. McArthur, S. P. McGuinness, J. A. Myburgh, M. K. Saxena, A. Turner, S. A. Webb and R. Bellomo (2017). "Protocol and statistical analysis plan for the Randomised Evaluation of Active Control of Temperature versus Ordinary Temperature Management (REACTOR) trial." Crit Care Resusc 19(1): 81-87.

Vellinga, N. A. R., E. C. Boerma, M. Koopmans, A. Donati, A. Dubin, N. I. Shapiro, R. M. Pearse, P. H. J. van der Voort, A. M. Dondorp, T. Bafi, M. Fries, T. Akarsu-Ayazoglu, A. Pranskunas, S. Hollenberg, G. Balestra, M. van Iterson, F. Sadaka, G. Minto, U. Aypar, F. J. Hurtado, G. Martinelli, D. Payen, F. van Haren, A. Holley, H. Gomez, R. L. Mehta, A. H. Rodriguez, C. Ruiz, H. S. Canales, J. Duranteau, P. E. Spronk, S. Jhanji, S. Hubble, M. Chierego, C. Jung, D. Martin, C. Sorbara, J. Bakker, C. Ince and S. s. g. micro (2017). "Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis." Crit Care 21(1): 255.

van Haren, F. Velloza, P. Chan, S. Mews, P. Lueck CJ. (2017). “Induced Hypertension for Preventing Complications of Delayed Cerebral Ischaemia in Aneurysmal Subarachnoid Haemorrhage (Protocol).” Cochrane Database Syst Rev (11) : 1-9.

van Haren, F. M. P. (2017). "A Chamber With a View: The Size of the Right Ventricle During Cardiopulmonary Resuscitation." Critical Care Medicine 45(7): 1258-1260.

van Haren, F. (2017). "Personalised fluid resuscitation in the ICU: still a fluid concept?" Crit Care 21(Suppl 3): 313.

Marini, J. J., D. De Backer, C. Ince, M. Singer, F. Van Haren, M. Westphal and P. Wischmeyer (2017). "Seven unconfirmed ideas to improve future ICU practice." Crit Care 21(Suppl 3): 315.

Laffey, J. G., F. Madotto, G. Bellani, T. Pham, E. Fan, L. Brochard, P. Amin, Y. Arabi, E. K. Bajwa, A. Bruhn, V. Cerny, K. Clarkson, L. Heunks, K. Kurahashi, J. H. Laake, J. A. Lorente, L. McNamee, N. Nin, J. E. Palo, L. Piquilloud, H. Qiu, J. I. S. Jiménez, A. Esteban, D. F. McAuley, F. van Haren, M. Ranieri, G. Rubenfeld, H. Wrigge, A. S. Slutsky and A. Pesenti (2017). "Geo-economic variations in epidemiology, patterns of care, and outcomes in patients with acute respiratory distress syndrome: insights from the LUNG SAFE prospective cohort study." The Lancet Respiratory Medicine 5(8): 627-638.

Khanna, A., S. W. English, X. S. Wang, K. Ham, J. Tumlin, H. Szerlip, L. W. Busse, L. Altaweel, T. E. Albertson, C. Mackey, M. T. McCurdy, D. W. Boldt, S. Chock, P. J. Young, K. Krell, R. G. Wunderink, M. Ostermann, R. Murugan, M. N. Gong, R. Panwar, J. Hastbacka, R. Favory, B. Venkatesh, B. T. Thompson, R. Bellomo, J. Jensen, S. Kroll, L. S. Chawla, G. F. Tidmarsh, A. M. Deane and A.-. Investigators (2017). "Angiotensin II for the Treatment of Vasodilatory Shock." N Engl J Med.

Kecskes, Z. and I. Mitchell (2017). "Introducing a new series on innovations in medical education." Med J Aust 206(1): 13.

Holloway, J. Cuningham, J. and F. van Haren (2017). “DonateLife ACT and the Impact of the National Reform Programme.” Transplant Journal of Australasia 26(2): 4-5.

Edelman, J., M. K. Wilson, M. P. Vallely, P. G. Bannon, G. McKay, S. J. Robertson, R. Hislop, C. Wong, B. L. Cartwright, P. Forrest and P. J. Torzillo (2017). "The expanding role of extracorporeal membrane oxygenation retrieval services in Australia." Anaesth Intensive Care 45(1): 92-93.

Dicks, S. G., K. Ranse, H. Northam, D. P. Boer and F. M. van Haren (2017). "The development of a narrative describing the bereavement of families of potential organ donors: A systematic review." Health Psychol Open 4(2): 2055102917742918.

Dicks, S. G., K. Ranse, F. M. v. Haren and D. P. Boer (2017). "In-hospital experiences of families of potential organ donors: A systematic review and qualitative synthesis." Health Psychology Open 4(1): 2055102917709375.

Delaney, L. J., M. J. Currie, H.-C. C. Huang, V. Lopez, E. Litton and F. Van Haren (2017). "The nocturnal acoustical intensity of the intensive care environment: an observational study." Journal of Intensive Care 5(1): 41.

Byrne, L., N. G. Obonyo, S. Diab, K. Dunster, M. Passmore, A. C. Boon, L. S. Hoe, K. Hay, F. Van Haren, J. P. Tung, L. Cullen, K. Shekar, K. Maitland and J. F. Fraser (2017). "An Ovine Model of Hyperdynamic Endotoxemia and Vital Organ Metabolism." Shock.

Byrne, L. and F. Van Haren (2017). "Fluid resuscitation in human sepsis: Time to rewrite history?" Ann Intensive Care 7(1): 4.

Bulic, D., M. Bennett, H. Rodgers, M. Nourse, P. Rubie, J. C. Looi and F. Van Haren (2017). "Delirium After Mechanical Ventilation in Intensive Care Units: The Cognitive and Psychosocial Assessment (CAPA) Study Protocol." JMIR Res Protoc 6(2): e31.

Bellani, G., J. G. Laffey, T. Pham, F. Madotto, E. Fan, L. Brochard, A. Esteban, L. Gattinoni, V. Bumbasirevic, L. Piquilloud, F. van Haren, A. Larsson, D. F. McAuley, P. R. Bauer, Y. M. Arabi, M. Ranieri, M. Antonelli, G. D. Rubenfeld, B. T. Thompson and H. Wrigge (2017). "Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome. Insights from the LUNG SAFE Study." American Journal of Respiratory & Critical Care Medicine 195(1): 67-77.

Reid, D. B., L. S. Chapple, S. N. O'Connor, R. Bellomo, H. Buhr, M. J. Chapman, A. R. Davies, G. M. Eastwood, S. Ferrie, K. Lange, J. McIntyre, D. M. Needham, S. L. Peake, S. Rai, E. J. Ridley, H. Rodgers and A. M. Deane (2016). "The effect of augmenting early nutritional energy delivery on quality of life and employment status one year after ICU admission." Anaesthesia & Intensive Care 44(3): 406-412.

Reade, M. C., G. M. Eastwood, R. Bellomo, M. Bailey, A. Bersten, B. Cheung, A. Davies, A. Delaney, A. Ghosh, F. van Haren, N. Harley, D. Knight, S. McGuiness, J. Mulder, S. O'Donoghue, N. Simpson and P. Young (2016). "Effect of Dexmedetomidine Added to Standard Care on Ventilator-Free Time in Patients With Agitated Delirium: A Randomized Clinical Trial." JAMA: Journal of the American Medical Association 315(14): 1460-1468.

Montana-Hoyos C., T. S., Bikshandi B., Fenwick B., Stehlik H., van Haren F. (2016). "User-centered, Research-based Design of Futuristic Intensive Care Units." International Journal of Architectonic, Spatial, and Environmental Design 10(3).

Mitchell, I., A. Schuster, K. Smith, P. Pronovost and A. Wu (2016). "Patient safety incident reporting: a qualitative study of thoughts and perceptions of experts 15 years after 'To Err is Human'." BMJ Qual Saf 25(2): 92-99.

Laffey, J. G., G. Bellani, T. Pham, E. Fan, F. Madotto, E. K. Bajwa, L. Brochard, K. Clarkson, A. Esteban, L. Gattinoni, F. van Haren, L. M. Heunks, K. Kurahashi, J. H. Laake, A. Larsson, D. F. McAuley, L. McNamee, N. Nin, H. Qiu, M. Ranieri, G. D. Rubenfeld, B. T. Thompson, H. Wrigge, A. S. Slutsky and A. Pesenti (2016). "Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study." Intensive Care Med 42(12): 1865-1876.

Kerr, A., J. T. McVey, A. M. Wood, F. M. P. Van Haren and F. Van Haren (2016). "Safety of nicotine replacement therapy in critically ill smokers: a retrospective cohort study." Anaesthesia & Intensive Care 44(6): 758-761.

Hoffman, K. R., B. Loong and F. V. Haren (2016). "Very old patients urgently referred to the intensive care unit: long-term outcomes for admitted and declined patients." Crit Care Resusc 18(3): 157-164.

Green, M., V. Marzano, I. A. Leditschke, I. Mitchell and B. Bissett (2016). "Mobilization of intensive care patients: a multidisciplinary practical guide for clinicians." J Multidiscip Healthc 9: 247-256.

Cardona-Morrell, M., J. Kim, R. M. Turner, M. Anstey, I. A. Mitchell and K. Hillman (2016). "Non-beneficial treatments in hospital at the end of life: a systematic review on extent of the problem." Int J Qual Health Care 28(4): 456-469.

Bissett, B., M. Green, V. Marzano, S. Byrne, I. A. Leditschke, T. Neeman, R. Boots and J. Paratz (2016). "Reliability and utility of the Acute Care Index of Function in intensive care patients: An observational study." Heart Lung 45(1): 10-14.

Bissett, B. M., I. A. Leditschke, T. Neeman, R. Boots and J. Paratz (2016). "Inspiratory muscle training to enhance recovery from mechanical ventilation: a randomised trial." Thorax 71(9): 812-819.

Bellani, G., J. G. Laffey, P. Tài, E. Fan, L. Brochard, A. Esteban, L. Gattinoni, A. Larsson, D. F. McAuley, M. Ranieri, G. Rubenfeld, B. T. Thompson, F. Wrigge, A. S. Slutsky, A. Pesenti, T. Pham, F. van Haren, H. Wrigge, L. S. Investigators and E. T. G. the (2016). "Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries." JAMA: Journal of the American Medical Association 315(8): 788-800.

Young, P., M. Saxena, R. Bellomo, R. Freebairn, N. Hammond, F. van Haren, M. Holliday, S. Henderson, D. Mackle, C. McArthur, S. McGuinness, J. Myburgh, M. Weatherall, S. Webb and R. Beasley (2015). "Acetaminophen for Fever in Critically Ill Patients with Suspected Infection." New England Journal of Medicine 373(23): 2215-2224.

Wassenaar, A., M. van den Boogaard, T. van Achterberg, A. J. C. Slooter, M. A. Kuiper, M. E. Hoogendoorn, K. S. Simons, E. Maseda, N. Pinto, C. Jones, A. Luetz, A. Schandl, W. Verbrugghe, L. M. Aitken, F. M. P. van Haren, A. R. T. Donders, L. Schoonhoven and P. Pickkers (2015). "Multinational development and validation of an early prediction model for delirium in ICU patients." Intensive Care Medicine 41(6): 1048-1056.

van Haren, F., J. Cohen, A. McKee, I. Mitchell, M. Pinder and I. Seppelt (2015). "Infection control in times of Ebola: how well are we training the next generation of intensivists in Australia and New Zealand?" Crit Care Resusc 17(2): 65-66.

van Haren F.M.P., S. J., Cursons J., Cursons R.T.M., Jameson M. (2015). "Preliminary report of a novel model using human umbilical vein endothelium in whole umbilical cord preparations to examine the in vitro effects of lipopolysaccharide and hypertonic saline on the gene expression of inflammatory mediators." Anaesthesia and Intensive Care 43(2).

Leech, M., B. Bissett, M. Kot and G. Ntoumenopoulos (2015). "Physiotherapist-initiated lung ultrasound to improve intensive care management of a deteriorating patient and prevent intubation: a case report." Physiother Theory Pract 31(5): 372-376.

Leech, M., B. Bissett, M. Kot and G. Ntoumenopoulos (2015). "Lung ultrasound for critical care physiotherapists: a narrative review." Physiother Res Int 20(2): 69-76.

Leditshke, I. A., T. Crispin and J. Bestic (2015). "Advance care directives in residential aged care." AFP 44(4): 186-190.

Jones, D., P. Hicks, J. Currey, J. Holmes, G. J. Fennessy, K. Hillman, A. Psirides, S. Rai, M. Y. Singh, D. V. Pilcher, D. Bhonagiri, G. K. Hart and E. Fugaccia (2015). "Findings of the first ANZICS conference on the role of intensive care in Rapid Response Teams." Anaesth Intensive Care 43(3): 369-379.

Hoffman, K. R., S. W. Chan, A. R. Hughes and S. J. Halcrow (2015). "Management of Cerebellar Tonsillar Herniation following Lumbar Puncture in Idiopathic Intracranial Hypertension." Case Rep Crit Care 2015: 895035.

Hargreaves, D. S., F. Greaves, C. Levay, I. Mitchell, U. Koch, T. Esch, S. Denny, J. C. Frich, J. Struijs and A. Sheikh (2015). "Comparison of Health Care Experience and Access Between Young and Older Adults in 11 High-Income Countries." J Adolesc Health 57(4): 413-420.

Finfer, S., D. Chittock, Y. Li, D. Foster, V. Dhingra, R. Bellomo, D. Cook, P. Dodek, P. Hebert, W. Henderson, D. Heyland, A. Higgins, C. McArthur, I. Mitchell, J. Myburgh, B. Robinson and J. Ronco (2015). "Intensive versus conventional glucose control in critically ill patients with traumatic brain injury: long-term follow-up of a subgroup of patients from the NICE-SUGAR study." Intensive Care Med 41(6): 1037-1047.

Dulhunty, J. M., J. A. Roberts, J. S. Davis, S. A. Webb, R. Bellomo, C. Gomersall, C. Shirwadkar, G. M. Eastwood, J. Myburgh, D. L. Paterson, T. Starr, S. K. Paul and J. Lipman (2015). "A Multicenter Randomized Trial of Continuous versus Intermittent beta-Lactam Infusion in Severe Sepsis." Am J Respir Crit Care Med 192(11): 1298-1305.

Delaney, L. v. H., Frank; Currie, Marian; Huang, Hsin-Chia Carol; Lopez, Violeta (2015). "Sleep Monitoring Techniques within Intensive Care." International Journal of Nursing and Clinical Practices 2(1).

Delaney, L. J., F. Van Haren and V. Lopez (2015). "Sleeping on a problem: the impact of sleep disturbance on intensive care patients - a clinical review." Ann Intensive Care 5: 3.

Bulic, D. B., M; Shehabi, Y (2015). "Delirium in the intensive care unit and long–term cognitive and psychosocial functioning: literature review." Australian Journal of Advanced Nursing 33(1): 44-52.

Bissett, B., I. A. Leditschke, T. Neeman, R. Boots and J. Paratz (2015). "Weaned but weary: one third of adult intensive care patients mechanically ventilated for 7 days or more have impaired inspiratory muscle endurance after successful weaning." Heart Lung 44(1): 15-20.

Westphal, M. and F. M. P. van Haren (2014). "Sepsis and Pharmacogenomics: Can the VAS(S)T Majority of Vasopressor Treatment Be Individualized?*." Critical Care Medicine 42(8): 1944-1945.

van Haren, F. and K. Zacharowski (2014). "What's new in volume therapy in the intensive care unit?" Best Practice & Research: Clinical Anaesthesiology 28(3): 275-283.

van den Boogaard, M., L. Schoonhoven, E. Maseda, C. Plowright, C. Jones, A. Luetz, P. V. Sackey, P. G. Jorens, L. M. Aitken, F. M. P. van Haren, R. Donders, J. G. van der Hoeven and P. Pickkers (2014). "Recalibration of the delirium prediction model for ICU patients (PRE-DELIRIC): a multinational observational study." Intensive Care Medicine 40(3): 361-369.

Robertson, C. S., H. J. Hannay, J. M. Yamal, S. Gopinath, J. C. Goodman, B. C. Tilley, T. B. I. T. I. Epo Severe, A. Baldwin, L. Rivera Lara, H. Saucedo-Crespo, O. Ahmed, S. Sadasivan, L. Ponce, J. Cruz-Navarro, H. Shahin, I. P. Aisiku, P. Doshi, A. Valadka, L. Neipert, J. M. Waguspack, M. L. Rubin, J. S. Benoit and P. Swank (2014). "Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial." JAMA 312(1): 36-47.

Presneill, J., L. Little, A. Nichol, C. French, D. J. Cooper, S. Haddad, J. Duranteau, O. Huet, M. Skrifvars, Y. Arabi and R. Bellomo (2014). "Statistical analysis plan for the Erythropoietin in Traumatic Brain Injury trial: a randomised controlled trial of erythropoietin versus placebo in moderate and severe traumatic brain injury." Trials 15(1): 501.

Peake, S. L., A. R. Davies, A. M. Deane, K. Lange, J. L. Moran, S. N. O'Connor, E. J. Ridley, P. J. Williams, M. J. Chapman, T. investigators, A. the and G. New Zealand Intensive Care Society Clinical Trials (2014). "Use of a concentrated enteral nutrition solution to increase calorie delivery to critically ill patients: a randomized, double-blind, clinical trial." Am J Clin Nutr 100(2): 616-625.

Parakh, S., A. Piggin, T. Neeman, I. Mitchell, P. Crispin and A. Davis (2014). "Outcomes of haematology/oncology patients admitted to intensive care unit at The Canberra Hospital." Intern Med J 44(11): 1087-1094.

Marty, F. M., C. Y. Man, C. van der Horst, B. Francois, D. Garot, R. Manez, V. Thamlikitkul, J. A. Lorente, F. Alvarez-Lerma, D. Brealey, H. H. Zhao, S. Weller, P. J. Yates and A. F. Peppercorn (2014). "Safety and pharmacokinetics of intravenous zanamivir treatment in hospitalized adults with influenza: an open-label, multicenter, single-arm, phase II study." J Infect Dis 209(4): 542-550.

Marck-Jansen, C., S. Neate, B. Dwyer, F. van Haren and W. W. Jan Ijzermans (2014). "Comparing Organ Donation Practices and Rates Between Australia and the Netherlands to Detect Best Practices and Areas for Improvement." Organs, Tissues and Cells 17(1).

Investigators, A., A. C. T. Group, S. L. Peake, A. Delaney, M. Bailey, R. Bellomo, P. A. Cameron, D. J. Cooper, A. M. Higgins, A. Holdgate, B. D. Howe, S. A. Webb and P. Williams (2014). "Goal-directed resuscitation for patients with early septic shock." N Engl J Med 371(16): 1496-1506.

Hodgson, C. L., K. Stiller, D. M. Needham, C. J. Tipping, M. Harrold, C. E. Baldwin, S. Bradley, S. Berney, L. R. Caruana, D. Elliott, M. Green, K. Haines, A. M. Higgins, K. M. Kaukonen, I. A. Leditschke, M. R. Nickels, J. Paratz, S. Patman, E. H. Skinner, P. J. Young, J. M. Zanni, L. Denehy and S. A. Webb (2014). "Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults." Crit Care 18(6): 658.